ROBUST ENZYMES OPTIMIZED FOR CONSISTENT, SCALABLE RNA MANUFACTURING.
The Prima RNApols® portfolio includes purpose-built RNA polymerases engineered to improve IVT performance across diverse RNA manufacturing workflows. By matching the enzyme to template design and cap strategy, teams can improve yield and capping efficiency while reducing dsRNA, unwanted byproducts, and key reagent inputs. Prima RNApols® support cleaner, higher-quality, lower-cost RNA production from R&D through process development and scale-up.
CAPPING
AG CAP ANALOG
AU CAP ANALOG
RNA YIELD
ACROSS DIVERSE
TEMPLATES
TEMPLATES
DSRNA
DSRNA REDUCTION
vs. conventional T7
COST SAVINGS
REAGENT EFFICIENCY
TRANSLATABILITY
PROTEIN EXPRESSION
PROMOTER
T7 PROMOTER
COMPATIBLE no redesign required
COMPATIBLE no redesign required
Key Strength
Strong
Supported
✕
Not Compatible
PRIMA CAP AU
AU-capped mRNA & saRNA
AG CAP ANALOG
CAPPING
AU CAP ANALOG
AU CAP ANALOG
RNA YIELD
ACROSS DIVERSE
TEMPLATES
ACROSS DIVERSE
TEMPLATES
DSRNA
DSRNA REDUCTION
vs. conventional T7
DSRNA REDUCTION
vs. conventional T7
COST SAVINGS
REAGENT EFFICIENCY
REAGENT EFFICIENCY
TRANSLATABILITY
PROTEIN EXPRESSION
PROTEIN EXPRESSION
Data coming soon
PROMOTER
T7 PROMOTER COMPATIBLE
no redesign required
T7 PROMOTER COMPATIBLE
no redesign required
✕
1
RUO KITS TODAY. ESTABLISHED CAPABILITIES TO SUPPORT YOUR GMP MANUFACTURING AS PROGRAMS ADVANCE.
Prima RNApols® support R&D, screening, and process-development workflows. Primrose Bio has established manufacturing capabilities to produce GMP-grade RNA polymerases. As your programs advance toward clinical, or commercial manufacturing, we supply Prima RNApols through ISO 13485-certified quality systems, analytical capability and manufacturing infrastructure.